For over a century, viruses have left a long trail of evidence implicating them as frequent
suspects in the development of type 1 diabetes. Through vigorous interrogation of viral …

Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) regulates a panoply of
leukocyte signaling pathways. A single nucleotide polymorphism (SNP) in PTPN22 …

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection is a leading
cause of pneumonia and death. The aim of this investigation is to identify the key genes in …

Abstract Purpose of Review We provide an overview of the current knowledge regarding the
natural history of human type 1 diabetes (T1D) and the documented associations between …

The goal of the present investigation is to identify the differentially expressed genes (DEGs)
between SARS-CoV-2 infected and normal control samples to investigate the molecular …

The protein tyrosine phosphatase PTPN22 inhibits T cell activation by dephosphorylating
some essential proteins in the T cell receptor (TCR)-mediated signaling pathway, such as …

Protein tyrosine phosphatases (PTPs) play central roles in the regulation of cell signaling,
organismal development, cellular differentiation and proliferation, and cancer. In the immune …

Geniposide, an iridoid glycoside purified from the fruit of Gardenia jasminoides J. Ellis, has
been reported to possess pleiotropic activity against different diseases. In particular …

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is encoded by a major
autoimmunity gene and is a known inhibitor of T cell receptor (TCR) signaling and drug …

Abstract Type 1 diabetes (T1D) etiology is complex. We developed a machine learning
approach that ranked the tissue-specific transcription regulatory effects for T1D SNPs and …