Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

X Zou, C Guan, J Gao, W Shi, Y Cui… - Frontiers in …, 2023 - frontiersin.org
Pancreatic cancer (PC) is extremely malignant and shows limited response to available
immunotherapies due to the hypoxic and immunosuppressive nature of its tumor …

Heterogeneity of tertiary lymphoid structures in cancer

X You, K Koop, A Weigert - Frontiers in Immunology, 2023 - frontiersin.org
The success of immunotherapy approaches, such as immune checkpoint blockade and
cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the …

Tertiary lymphoid structures (TLSs) and stromal blood vessels have significant and heterogeneous impact on recurrence, lymphovascular and perineural invasion …

AC Barb, M Pasca Fenesan, M Pirtea, MM Margan… - Cells, 2023 - mdpi.com
Simple Summary Immunotherapies for breast cancer (BC) are among the most promising
treatments for mammary gland malignancies, but their tissue and cellular targets are …

Tumor-infiltrating B lymphocytes: promising immunotherapeutic targets for primary liver cancer treatment

G Milardi, A Lleo - Cancers, 2023 - mdpi.com
Simple Summary Primary liver cancer is a frequent cause of cancer-related death with high
mortality rates. Cellular components of the heterogeneous tumor microenvironment (TME) …

Key oncogenic signaling pathways affecting tumor-infiltrating lymphocytes infiltration in hepatocellular carcinoma: basic principles and recent advances

X Wang, Z Yuan, Z Li, X He, Y Zhang, X Wang… - Frontiers in …, 2024 - frontiersin.org
The incidence of hepatocellular carcinoma (HCC) ranks first among primary liver cancers,
and its mortality rate exhibits a consistent annual increase. The treatment of HCC has …

Lymphocyte Function in Tertiary Lymphoid Structures Predicts Hepatocellular Carcinoma Outcome

J Li, H Xu, J Han, P Sun, X Zhang, H Wang, T Bian… - Laboratory …, 2024 - Elsevier
An increasing number of studies have revealed a correlation between tertiary lymphoid
structures (TLSs) and the outcome of hepatocellular carcinoma (HCC). Nevertheless, the …

Characteristics and clinical significance of tertiary lymphoid structures in OSCC

M Yao, T Yang, Q Li, X Zhang, Z Zheng, J Li… - Oral …, 2024 - Wiley Online Library
Objectives This study aimed to investigate the characteristics of tertiary lymphoid structures
(TLSs) in oral squamous cell carcinoma (OSCC) and their association with clinical and …

[HTML][HTML] Low CD8+ Density Variation and R1 Surgical Margin as Independent Predictors of Early Post-Resection Recurrence in HCC Patients Meeting Milan Criteria

R Stulpinas, I Jakiunaite, A Sidabraite, A Rasmusson… - Current …, 2024 - mdpi.com
Our study included 41 patients fulfilling the Milan criteria preoperatively and aimed to identify
individuals at high risk of post-resection HCC relapse, which occurred in 18 out of 41 …

The effect of prescription dose and dose fractionation on the abscopal effect in a mouse model of non-small cell lung cancer

J Cai - 2024 - kups.ub.uni-koeln.de
Lung cancer is one of the most prevalent and deadliest malignant tumors worldwide, with
non-small cell lung cancer being the most common subtype. Besides surgery and …

Dissecting the role of hepatic Nfκb1 in inflammation and ageing

L Marchetti - 2023 - theses.ncl.ac.uk
The NF-κB family is a group of 5 subunits functioning as transcription factors in a variety of
important cellular pathways, including inflammation, cell proliferation and cancer. They work …