Non-epithelial ovarian cancers: how much do we really know?

A Cheung, S Shah, J Parker, P Soor, A Limbu… - International journal of …, 2022 - mdpi.com
Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly
includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely …

The prenatal origins of cancer

GM Marshall, DR Carter, BB Cheung, T Liu… - Nature Reviews …, 2014 - nature.com
The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

11q deletion in neuroblastoma: a review of biological and clinical implications

V Mlakar, S Jurkovic Mlakar, G Lopez, JM Maris… - Molecular cancer, 2017 - Springer
Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events
that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is …

[HTML][HTML] PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

N Sharma, R Nanta, J Sharma, S Gunewardena… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis.
It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling …

Lin28 sustains early renal progenitors and induces Wilms tumor

A Urbach, A Yermalovich, J Zhang… - Genes & …, 2014 - genesdev.cshlp.org
Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal
differentiation of the embryonic kidney. Here we show that overexpression of the …

Lin28B/Let-7 regulates expression of Oct4 and Sox2 and reprograms oral squamous cell carcinoma cells to a stem-like state

CS Chien, ML Wang, PY Chu, YL Chang, WH Liu… - Cancer research, 2015 - AACR
Lin28, a key factor for cellular reprogramming and generation of induced pluripotent stem
cell (iPSC), makes a critical contribution to tumorigenicity by suppressing Let-7. However, it …

To be or not to be a germ cell: the extragonadal germ cell tumor paradigm

M De Felici, FG Klinger, F Campolo… - International Journal of …, 2021 - mdpi.com
In the human embryo, the genetic program that orchestrates germ cell specification involves
the activation of epigenetic and transcriptional mechanisms that make the germline a unique …

A LIN28B-RAN-AURKA signaling network promotes neuroblastoma tumorigenesis

RW Schnepp, P Khurana, EF Attiyeh, P Raman… - Cancer cell, 2015 - cell.com
A more complete understanding of aberrant oncogenic signaling in neuroblastoma, a
malignancy of the developing sympathetic nervous system, is paramount to improving …

Paediatric extracranial germ-cell tumours

F Shaikh, MJ Murray, JF Amatruda, N Coleman… - The Lancet …, 2016 - thelancet.com
Management of paediatric extracranial germ-cell tumours carries a unique set of challenges.
Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age …

Circulating microRNA let-7e is decreased in knee osteoarthritis, accompanied by elevated apoptosis and reduced autophagy

L Feng, C Feng, CX Wang, DY Xu… - International …, 2020 - spandidos-publications.com
Knee osteoarthritis (KOA) is a major cause of leg disability in the elderly population.
Recently, the expression levels of circulating microRNA (miRNA) let-7e have been reported …