Deafness encompasses a series of etiologically heterogeneous disorders with mutations in
more than 400 independent genes. However, several studies indicate that a large proportion …

The last few years have witnessed dramatic advances in our understanding of the structure
and function of the mammalian mito-ribosome. At the same time, the first attempts to …

Congenital nonsyndromic hearing loss (NSHL) has been considered as one of the most
prevalent chronic disorder in children. It affects the physical and mental conditions of a large …

Mitochondrial disorders are a class of heterogeneous disorders caused by genetic
variations in the mitochondrial genome (mtDNA) as well as the nuclear genome. The …

Hearing loss is the most common sensory disorder and is genetically heterogeneous. Apart
from nuclear gene mutations, a number of inherited mitochondrial mutations have also been …

Methods: Forty seven families including 26 consanguineous families with at least two
hearing impaired children and one normal hearing child and 21 non-consanguineous …

Unravelling the mechanism of non-syndromic hearing loss (NSHL) through genetic studies
have till date been perplexed by several factors such as genetic heterogeneity, multiple …

Diabetic retinopathy (DR) is a common complication of diabetes and a major cause of
acquired blindness in adults. Mitochondria are cellular organelles involved in energy …

Genetic heterogeneity, multiple phenotypes, consanguinity and marriages between hearing
impaired persons have confounded the genetic studies on non-syndromic hearing loss …

Background: Congenital hearing loss is a debilitating disease affecting 1–3 out of 1,000 live
births. According to WHO's associated figures, in both ears, 278 million people globally …