[HTML][HTML] An insight into current advances on pharmacology, pharmacokinetics, toxicity and detoxification of aconitine

S Li, L Yu, Q Shi, Y Liu, Y Zhang, S Wang… - Biomedicine & …, 2022 - Elsevier
Aconitine is a diterpenoid alkaloid, which mainly exists in the plants of Aconitum. In the last
decade, a plethora of studies on the pharmacological activities of aconitine has been …

Recent development in zebrafish model for bioactivity and safety evaluation of natural products

FJ Lin, H Li, DT Wu, QG Zhuang, HB Li… - Critical Reviews in …, 2022 - Taylor & Francis
The zebrafish is a species of freshwater fish, popular in aquariums and laboratories. Several
advantageous features have facilitated zebrafish to be extensively utilized as a valuable …

Comprehensive insight into the pharmacology, pharmacokinetics, toxicity, detoxification and extraction of hypaconitine from Aconitum plants

G Xiang, S Guo, J Qin, H Gao, Y Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Hypaconitine (HA), a diterpenoid alkaloid, mainly derived
from Aconitum plants such as Acoitum carmichaeli Debx. And Aconitum nagarum Stapf., has …

Aconitine induces autophagy via activating oxidative DNA damage-mediated AMPK/ULK1 signaling pathway in H9c2 cells

W Wang, J Jiang, Y Huang, F Peng, T Hu, J Wu… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Aconitum species, with a medicinal history of 2000 years,
was traditionally used in the treatment of rheumatism, arthritis, bruises, and pains. However …

Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety

J Kanungo, BC Sorkin, J Krzykwa… - Expert Opinion on …, 2024 - Taylor & Francis
Botanicals are widely consumed as dietary supplements, medicines, and consumer
products. Their chemical complexity and variability present challenges in safety assessment …

[HTML][HTML] 2, 5-dichloro-1, 4-benuinone exposure to zebrafish embryos/larvae causes neurodevelopmental toxicity

Y Chen, L Xiao, G Gao, L He, K Zhao, X Shang… - … and Environmental Safety, 2022 - Elsevier
dichloro-1, 4-benuinone (2, 5-DCBQ) is an emerging disinfection by-product belonging to
the class of halobenzoquinones (HBQs). However, there is limited evidence regarding the …

Aconitum carmichaelii triggers neurotoxicity and Parkinson‐like symptoms through initiation of ROS‐mitochondrial apoptosis and the Nox5/DJ‐1 signaling pathway

M Pang, X Song, Y Miao, Y Wang, C Zhou, Z Geng… - …, 2023 - Wiley Online Library
Background Aconitum carmichaelii, the mother root of Aconitum, has a long‐applied history
for treating many diseases in China. Increased use of it has prompted significant concerns …

Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in …

J Zhou, C Peng, Q Li, X Yan, L Yang, M Li… - Frontiers in …, 2022 - frontiersin.org
Aconitine is one of the main bioactive and toxic ingredients of Aconitum species.
Increasingly, aconitine has been reported to induce neurotoxicity. However, whether …

Targeted preparation and recognition mechanism of broad-spectrum antibody specific to Aconitum alkaloids based on molecular modeling and its application in …

Z Ren, H Zhang, L Yang, Z Wang, J Xiong, P Zheng… - Analytica Chimica …, 2022 - Elsevier
Abstract Ester-type Aconitum alkaloids (AAs), the main medicinal ingredients of Aconitum L.
herbs, could cause brain and heart damage in humans and animals and have raised …

Study on the embryotoxic effects and potential mechanisms of Aconitum diterpenoid alkaloids in rat whole embryo culture through morphological and transcriptomic …

Q Feng, J Li, C Xiao, Z Wang, X Li, L Xiong… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The lateral root of Aconitum carmichaelii Debeaux, or Fuzi,
is recognized in Asia for its anti-inflammatory, analgesic, and cardiotonic effects. Its main …