ErbB receptors and cancer

Z Wang - ErbB receptor signaling: methods and protocols, 2017 - Springer
The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy

BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …

The diverse roles of arrestin scaffolds in G protein–coupled receptor signaling

YK Peterson, LM Luttrell - Pharmacological reviews, 2017 - ASPET
The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Seven-transmembrane receptors

KL Pierce, RT Premont, RJ Lefkowitz - Nature reviews Molecular cell …, 2002 - nature.com
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most
versatile family of membrane receptors, are also the most common target of therapeutic …

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

LM Luttrell, RJ Lefkowitz - Journal of cell science, 2002 - journals.biologists.com
β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled
receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein …

Regulation of mATG9 trafficking by Src-and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

C Zhou, K Ma, R Gao, C Mu, L Chen, Q Liu, Q Luo… - Cell research, 2017 - nature.com
Autophagy requires diverse membrane sources and involves membrane trafficking of
mATG9, the only membrane protein in the ATG family. However, the molecular regulation of …

Beyond desensitization: physiological relevance of arrestin-dependent signaling

LM Luttrell, D Gesty-Palmer - Pharmacological reviews, 2010 - ASPET
Heptahelical G protein-coupled receptors are the most diverse and therapeutically important
family of receptors in the human genome. Ligand binding activates heterotrimeric G proteins …

The role of prolactin in mammary carcinoma

CV Clevenger, PA Furth, SE Hankinson… - Endocrine …, 2003 - academic.oup.com
The contribution of prolactin (PRL) to the pathogenesis and progression of human breast
cancer at the cellular, transgenic, and epidemiological levels is increasingly appreciated …

Dynamin and its role in membrane fission

JE Hinshaw - Annual review of cell and developmental biology, 2000 - annualreviews.org
▪ Abstract Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in
receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and …

Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms

RG Parton, AA Richards - Traffic, 2003 - Wiley Online Library
Clathrin‐coated pits and caveolae are two of the most recognizable features of the plasma
membrane of mammalian cells. While our understanding of the machinery regulating and …