[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
Ovarian hormone fluctuation, neurosteroids, and HPA axis dysregulation in perimenopausal depression: a novel heuristic model
JL Gordon, SS Girdler… - American Journal of …, 2015 - Am Psychiatric Assoc
Objective: In this conceptual review, the authors propose a novel mechanistic candidate in
the etiology of depression with onset in the menopause transition (“perimenopausal …
the etiology of depression with onset in the menopause transition (“perimenopausal …
[HTML][HTML] The role of HPA axis and allopregnanolone on the neurobiology of major depressive disorders and PTSD
Under stressful conditions, the hypothalamic-pituitary-adrenal (HPA) axis acts to promote
transitory physiological adaptations that are often resolved after the stressful stimulus is no …
transitory physiological adaptations that are often resolved after the stressful stimulus is no …
Allopregnanolone in mood disorders: Mechanism and therapeutic development
S Chen, L Gao, X Li, Y Ye - Pharmacological Research, 2021 - Elsevier
The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …
[HTML][HTML] Beyond the HPA axis: progesterone-derived neuroactive steroids in human stress and emotion
MM Wirth - Frontiers in endocrinology, 2011 - frontiersin.org
Stress and social isolation are well-known risk factors for psychopathology. However, more
research is needed as to the physiological mechanisms by which social support buffers the …
research is needed as to the physiological mechanisms by which social support buffers the …
[HTML][HTML] Social plasticity relies on different neuroplasticity mechanisms across the brain social decision-making network in zebrafish
MC Teles, SD Cardoso, RF Oliveira - Frontiers in behavioral …, 2016 - frontiersin.org
Social living animals need to adjust the expression of their behavior to their status within the
group and to changes in social context and this ability (social plasticity) has an impact on …
group and to changes in social context and this ability (social plasticity) has an impact on …
Long-term ovariectomy increases anxiety-and despair-like behaviors associated with lower Fos immunoreactivity in the lateral septal nucleus in rats
A Puga-Olguín, JF Rodríguez-Landa… - Behavioural Brain …, 2019 - Elsevier
In woman, surgical menopause is associated with anxiety and depression symptoms.
Ovariectomy in rats has been proposed as an experimental model of surgical menopause …
Ovariectomy in rats has been proposed as an experimental model of surgical menopause …
[HTML][HTML] The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins
FB Almeida, MS Nin, HMT Barros - Neurobiology of Stress, 2020 - Elsevier
Abstract Allopregnanolone (3α, 5α-tetrahydroprogesterone; pharmaceutical formulation:
brexanolone) is a neurosteroid that has recently been approved for the treatment of …
brexanolone) is a neurosteroid that has recently been approved for the treatment of …
Multifunctional aspects of allopregnanolone in stress and related disorders
Abstract Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a major cholesterol-derived
neurosteroid in the central nervous system and is synthesized from progesterone by …
neurosteroid in the central nervous system and is synthesized from progesterone by …
[HTML][HTML] Considerations of timing post-ovariectomy in mice and rats in studying anxiety-and depression-like behaviors associated with surgical menopause in women
JF Rodríguez-Landa - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Menopause is a clinical term that indicates the end of the reproductive period of women that
occurs naturally; however, it can be induced by bilateral oophorectomy, which is commonly …
occurs naturally; however, it can be induced by bilateral oophorectomy, which is commonly …