Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

Objective: In this conceptual review, the authors propose a novel mechanistic candidate in
the etiology of depression with onset in the menopause transition (“perimenopausal …

Under stressful conditions, the hypothalamic-pituitary-adrenal (HPA) axis acts to promote
transitory physiological adaptations that are often resolved after the stressful stimulus is no …

The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …

Stress and social isolation are well-known risk factors for psychopathology. However, more
research is needed as to the physiological mechanisms by which social support buffers the …

Social living animals need to adjust the expression of their behavior to their status within the
group and to changes in social context and this ability (social plasticity) has an impact on …

In woman, surgical menopause is associated with anxiety and depression symptoms.
Ovariectomy in rats has been proposed as an experimental model of surgical menopause …

Abstract Allopregnanolone (3α, 5α-tetrahydroprogesterone; pharmaceutical formulation:
brexanolone) is a neurosteroid that has recently been approved for the treatment of …

Abstract Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a major cholesterol-derived
neurosteroid in the central nervous system and is synthesized from progesterone by …

Menopause is a clinical term that indicates the end of the reproductive period of women that
occurs naturally; however, it can be induced by bilateral oophorectomy, which is commonly …