Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities

H Isazadeh, F Oruji, S Shabani, J Behroozi… - Molecular Biology …, 2023 - Springer
Advancements in the clinical applications of small interfering RNA (siRNA) in cancer therapy
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …

Effects of nanoparticle size, shape, and zeta potential on drug delivery

K Öztürk, M Kaplan, S Çalış - International Journal of Pharmaceutics, 2024 - Elsevier
Nanotechnology has brought about a significant revolution in drug delivery, and research in
this domain is increasingly focusing on understanding the role of nanoparticle (NP) …

Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications

A Haider, S Khan, DN Iqbal, M Shrahili, S Haider… - European Polymer …, 2024 - Elsevier
Chitosan (CS), a biocompatible and biodegradable polymer produced from chitin, has
attracted interest in drug delivery due to its unique properties and diverse applications. Over …

Chitosan nanoplatforms in agriculture for multi-potential applications-adsorption/removal, sustained release, sensing of pollutants & delivering their alternatives–a …

G Kandasamy, R Manisekaran, MK Arthikala - Environmental Research, 2024 - Elsevier
An increase in the global population has led to an increment in the food consumption, which
has demanded high food production. To meet the production demands, different techniques …

Recent advances in micro-and nano-drug delivery systems based on natural and synthetic biomaterials

M Harun-Or-Rashid, MN Aktar, MS Hossain, N Sarkar… - Polymers, 2023 - mdpi.com
Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell
more easily, has advanced considerably in recent decades. Innovative medication delivery …

[HTML][HTML] Nucleic acid armor: fortifying RNA therapeutics through delivery and targeting innovations for immunotherapy

Y Jiang, B Jiang, Z Wang, Y Li, JCW Cheung… - International Journal of …, 2024 - mdpi.com
RNA is a promising nucleic acid-based biomolecule for various treatments because of its
high efficacy, low toxicity, and the tremendous availability of targeting sequences …

Stimulus-responsive nanodelivery and release systems for cancer gene therapy: efficacy improvement strategies

H Zeng, Y Zhang, N Liu, Q Wei, F Yang… - International Journal of …, 2024 - Taylor & Francis
Introduction of exogenous genes into target cells to overcome various tumor diseases
caused by genetic defects or abnormalities and gene therapy, a new treatment method …

Gene-editing technology, from macromolecule therapeutics to organ transplantation: Applications, limitations, and prospective uses

GI Harisa, TM Faris, AY Sherif, RF Alzhrani… - International Journal of …, 2023 - Elsevier
Gene editing technologies (GETs) could induce gene knockdown or gene knockout for
biomedical applications. The clinical success of gene silence by RNAi therapies pays …

Building a Better Silver Bullet: Current Status and Perspectives of Non‐Viral Vectors for mRNA Vaccines

J Gu, Z Xu, Q Liu, S Tang, W Zhang… - Advanced …, 2024 - Wiley Online Library
In recent years, messenger RNA (mRNA) vaccines have exhibited great potential to replace
conventional vaccines owing to their low risk of insertional mutagenesis, safety and efficacy …

[HTML][HTML] Polymers as efficient non-viral gene delivery vectors: the role of the chemical and physical architecture of macromolecules

M Khan - Polymers, 2024 - mdpi.com
Gene therapy is the technique of inserting foreign genetic elements into host cells to achieve
a therapeutic effect. Although gene therapy was initially formulated as a potential remedy for …