Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Macrophage infiltration of white adipose tissue (WAT) is implicated in the metabolic
complications of obesity. The precipitating event (s) and function (s) of macrophage …

Adipocytes are embedded in a unique extracellular matrix whose main function is to provide
mechanical support, in addition to participating in a variety of signaling events. During …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is
replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) …

Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health
expenditures worldwide. Obesity is a significant risk factor for CKD development, partially …

Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes (T2D), are
associated with metastatic breast cancer in postmenopausal women. Here, we investigated …