Proteasome inhibitor drugs

LD Fricker - Annual review of pharmacology and toxicology, 2020 - annualreviews.org
Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

Saccharomyces cerevisiae biomass as a source of next‐generation food preservatives: Evaluating potential proteins as a source of antimicrobial peptides

PR Pereira, CS Freitas… - … reviews in food science …, 2021 - Wiley Online Library
Saccharomyces cerevisiae is the main biotechnological tool for the production of Baker's or
Brewer's biomasses, largely applied in beverage and fermented‐food production. Through …

The role of micropeptides in biology

R Vitorino, S Guedes, F Amado, M Santos… - Cellular and Molecular …, 2021 - Springer
Micropeptides are small polypeptides coded by small open-reading frames. Progress in
computational biology and the analyses of large-scale transcriptomes and proteomes have …

Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles

PC Chan-Andersen, EV Romanova… - Journal of Biological …, 2022 - ASBMB
Neuropeptides are a chemically diverse class of cell-to-cell signaling molecules that are
widely expressed throughout the central nervous system, often in a cell-specific manner …

Structural insights into substrate recognition and processing by the 20S proteasome

I Sahu, MH Glickman - Biomolecules, 2021 - mdpi.com
Four decades of proteasome research have yielded extensive information on ubiquitin-
dependent proteolysis. The archetype of proteasomes is a 20S barrel-shaped complex that …

Peptidome: Chaos or inevitability

I Lyapina, V Ivanov, I Fesenko - International journal of molecular …, 2021 - mdpi.com
Thousands of naturally occurring peptides differing in their origin, abundance and possible
functions have been identified in the tissue and biological fluids of vertebrates, insects, fungi …

Intracellular peptides in cell biology and pharmacology

CB de Araujo, AS Heimann, RA Remer, LC Russo… - Biomolecules, 2019 - mdpi.com
Intracellular peptides are produced by proteasomes following degradation of nuclear,
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …

Multiomic Approach for Bioprospection: Investigation of Toxins and Peptides of Brazilian Sea Anemone Bunodosoma caissarum

ME Mazzi Esquinca, CN Correa, G Marques de Barros… - Marine Drugs, 2023 - mdpi.com
Sea anemones are sessile invertebrates of the phylum Cnidaria and their survival and
evolutive success are highly related to the ability to produce and quickly inoculate venom …

Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis

KY Lee - Cell & bioscience, 2022 - Springer
There are hundreds of central nervous system (CNS) diseases, but there are few diseases
for which the etiology or pathogenesis is understood as well as those of other organ-specific …

Identification of Antibacterial Peptide Candidates Encrypted in Stress-Related and Metabolic Saccharomyces cerevisiae Proteins

MFS Santos, CS Freitas, GC Verissimo da Costa… - Pharmaceuticals, 2022 - mdpi.com
The protein-rich nature of Saccharomyces cerevisiae has led this yeast to the spotlight
concerning the search for antimicrobial peptides. Herein, a< 10 kDa peptide-rich extract …