Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …

Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic
progression remain poorly understood. We isolated pure populations of cancer cells from …

MicroRNAs play important roles in cell differentiation by acting as translational inhibitors of
specific target genes. Here we show that human granulocytic differentiation is controlled by …

During development of the mammalian nervous system, neural stem cells generate neurons
first and glia second, thereby allowing the initial establishment of neural circuitry, and …

Astrocytes can be generated from various tissue sources including human pluripotent stem
cells (PSC). In this manuscript, we describe a chemically defined xeno-free medium culture …

Genome-wide association studies (GWASs) have identified several susceptibility loci for
bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by …

Here we use a chromosome-level genome assembly of a prairie rattlesnake (Crotalus
viridis), together with Hi-C, RNA-seq, and whole-genome resequencing data, to study key …

The mechanisms controlling the transition from neurogenesis to gliogenesis in the
vertebrate CNS are incompletely understood. We identified a family of transcription factors …