Immunoinformatics and vaccine development: an overview

AN Oli, WO Obialor, MO Ifeanyichukwu… - ImmunoTargets and …, 2020 - Taylor & Francis
The use of vaccines have resulted in a remarkable improvement in global health. It has
saved several lives, reduced treatment costs and raised the quality of animal and human …

Strategies targeting hemagglutinin as a universal influenza vaccine

BL Bullard, EA Weaver - Vaccines, 2021 - mdpi.com
Influenza virus has significant viral diversity, both through antigenic drift and shift, which
makes development of a vaccine challenging. Current influenza vaccines are updated …

The combination of artificial intelligence and systems biology for intelligent vaccine design

G Russo, P Reche, M Pennisi… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction A new body of evidence depicts the applications of artificial intelligence and
systems biology in vaccine design and development. The combination of both approaches …

Comorbidities and susceptibility to COVID-19: a generalized gene set data mining approach

MF Beckman, FB Mougeot, JLC Mougeot - Journal of clinical medicine, 2021 - mdpi.com
The COVID-19 pandemic has led to over 2.26 million deaths for almost 104 million
confirmed cases worldwide, as of 4 February 2021 (WHO). Risk factors include pre-existing …

[HTML][HTML] Role of artificial intelligence in peptide vaccine design against RNA viruses

E Mohanty, A Mohanty - Informatics in Medicine Unlocked, 2021 - Elsevier
RNA viruses have high rate of replication and mutation that help them adapt and change
according to their environmental conditions. Many viral mutants are the cause of various …

Introducing of an integrated artificial neural network and Chou's pseudo amino acid composition approach for computational epitope-mapping of Crimean-Congo …

M Nosrati, H Mohabatkar, M Behbahani - International …, 2020 - Elsevier
This study was aimed to introduce a novel algorithm for determining linear B-and T-cell
epitopes from Crimean-Congo haemorrhagic fever virus (CCHFV) antigens. To this end, 387 …

Indirect-acting pan-antivirals vs. respiratory viruses: A fresh perspective on computational multi-target drug discovery

VV Kleandrova, MT Scotti… - Current Topics in …, 2021 - ingentaconnect.com
Respiratory viruses continue to afflict mankind. Among them, pathogens such as
coronaviruses [including the current pandemic agent known as severe acute respiratory …

Population disequilibrium as promoter of adaptive explorations in hepatitis C virus

C García-Crespo, I Gallego, ME Soria, AI de Ávila… - Viruses, 2021 - mdpi.com
Replication of RNA viruses is characterized by exploration of sequence space which
facilitates their adaptation to changing environments. It is generally accepted that such …

[HTML][HTML] Intranasal administration of immunogenic poly-epitope from influenza H1N1 and H3N2 viruses adjuvanted with chitin and chitosan microparticles in BALB/c …

S Sadeghi, M Bandehpour, MHM Hoseini… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
Objective (s): Prevalence of influenza virus, creates the need to achieve an efficient vaccine
against it. We examined whether the predicted antigenic epitopes of HA, NP, and M2 …

Facile and Modular Pipeline for Protein-Specific Antibody Customization

S Tang, T Han, Z Wang, N Yue, Z Liu… - ACS Applied Bio …, 2020 - ACS Publications
Antibodies are fundamental tools for basic science; however, high-quality antibodies
suitable for multiple experimental applications are often inaccessible to research …