DNA damage is the prime activator of the enzyme poly (ADP-ribose) polymerase1 (PARP-1)
whose overactivation has been proven to be associated with the pathogenesis of numerous …

Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide
Adenine Dinucleotide (NAD) and has long been associated with neuronal development …

Aims Poly (ADP-ribose) polymerase-(PARP)-1 is predominantly triggered by DNA damage.
Overexpression of PARP-1 is known for its association with the pathogenesis of several …

Parthanatos is a modality of regulated cell death initiated by poly (ADP-ribose) polymerase 1
(PARP-1) hyperactivation and characterized by apoptosis inducing factor (AIF)-dependent …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …

Disruption of cellular functions with aging-induced accumulation of neuronal stressors
causes cell death which is a common feature of neurodegenerative diseases. Studies in a …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a first responder that recognizes DNA
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …

There are common mechanisms shared by genetically or pathologically distinct
neurodegenerative diseases, such as excitotoxicity, mitochondrial deficits and oxidative …

ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which
controls major cellular and biological processes, including DNA damage repair, cell …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …