The insulin receptor (IR) is expressed in various regions of the developing and adult brain,
and its functions have become the focus of recent research. Insulin enters the central …

This article reviews the rapidly accumulating literature on the relationship between mood
disorders and diabetes mellitus. Recent studies have demonstrated that depression and its …

Food intake is tightly regulated by complex and coordinated gut-brain interactions. Nutrients
rapidly modulate activity in key populations of hypothalamic neurons that regulate food …

To investigate the dependence of LH pulsatility on energy availability (dietary energy intake
minus exercise energy expenditure), we measured LH pulsatility after manipulating the …

High-fat diet (HFD) feeding induces rapid reprogramming of systemic metabolism. Here, we
demonstrate that HFD feeding of mice downregulates glucose transporter (GLUT)-1 …

The brain occupies a special hierarchical position in the organism. It is separated from the
general circulation by the blood-brain barrier, has high energy consumption and a low …

The hypothalamus and other regions within the central nervous system (CNS) link the
sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that …

Glucose-responsive (GR) neurons in the hypothalamus are thought to be critical in glucose
homeostasis, but it is not known how they function in this context. Kir6. 2 is the pore-forming …

Glucosensing neurons are specialized cells that use glucose as a signaling molecule to
alter their action potential frequency in response to variations in ambient glucose levels …

To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca2+ imaging and
single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic nucleus …