[PDF][PDF] Curing HIV: seeking to target and clear persistent infection
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
Immunopathogenesis of HIV infection
G Pantaleo, AS Fauci - Annual review of microbiology, 1996 - annualreviews.org
The rate of progression of HIV disease may be substantially different among HIV-infected
individuals. Following infection of the host with any virus, the delicate balance between virus …
individuals. Following infection of the host with any virus, the delicate balance between virus …
Population dynamics of immune responses to persistent viruses
MA Nowak, CRM Bangham - Science, 1996 - science.org
Mathematical models, which are based on a firm understanding of biological interactions,
can provide nonintuitive insights into the dynamics of host responses to infectious agents …
can provide nonintuitive insights into the dynamics of host responses to infectious agents …
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
DA Price, PJR Goulder, P Klenerman… - Proceedings of the …, 1997 - National Acad Sciences
Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the
acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking …
acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking …
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase
MA Wainberg, WC Drosopoulos, H Salomon, M Hsu… - Science, 1996 - science.org
Monotherapy with (−) 2′, 3′-dideoxy-3′-thiacytidine (3TC) leads to the appearance of a
drug-resistant variant of human immunodeficiency virus-type 1 (HIV-1) with the methionine …
drug-resistant variant of human immunodeficiency virus-type 1 (HIV-1) with the methionine …
Essential flexibility in the T-cell recognition of antigen.
GJ Kersh, PM Allen - Nature, 1996 - search.ebscohost.com
Reviews a large body of experimental data on the flexibility of T-cell receptor (TCR)
recognition. Conclusion that flexibility may in fact play an essential part in a T-cell …
recognition. Conclusion that flexibility may in fact play an essential part in a T-cell …
The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of major histocompatibility complex (MHC) class I …
T Kerkau, I Bacik, JR Bennink, JW Yewdell… - The Journal of …, 1997 - rupress.org
The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a small integral
membrane phosphoprotein with two established functions: degradation of the viral …
membrane phosphoprotein with two established functions: degradation of the viral …
Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape
D Meyer-Olson, NH Shoukry, KW Brady… - The Journal of …, 2004 - rupress.org
Escape mutations are believed to be important contributors to immune evasion by rapidly
evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific …
evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific …
Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection
G Pantaleo, H Soudeyns… - Proceedings of the …, 1997 - National Acad Sciences
Down-regulation of the initial burst of viremia during primary HIV infection is thought to be
mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this …
mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this …
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1
Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence
suggests that viral evolution in response to specific selective pressures follows generally …
suggests that viral evolution in response to specific selective pressures follows generally …