Autophagy, inflammation, and immune dysfunction in the pathogenesis of pancreatitis

AS Gukovskaya, I Gukovsky, H Algül, A Habtezion - Gastroenterology, 2017 - Elsevier
Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …

Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome

M Bhatia, S Moochhala - The Journal of Pathology: A Journal of …, 2004 - Wiley Online Library
Inflammatory response leading to organ dysfunction and failure continues to be the major
problem after injury in many clinical conditions such as sepsis, severe burns, acute …

Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

H Choi, Y Kim, A Mirzaaghasi, J Heo, YN Kim… - Science …, 2020 - science.org
As extracellular vesicles that play an active role in intercellular communication by
transferring cellular materials to recipient cells, exosomes offer great potential as a natural …

[HTML][HTML] The interplay between inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: clinical implications

P Dumnicka, D Maduzia, P Ceranowicz… - International journal of …, 2017 - mdpi.com
Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild
local inflammation to severe systemic involvement resulting in substantial mortality. Early …

Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer

I Gukovsky, N Li, J Todoric, A Gukovskaya, M Karin - Gastroenterology, 2013 - Elsevier
Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …

Neutrophil extracellular traps induce trypsin activation, inflammation, and tissue damage in mice with severe acute pancreatitis

M Merza, H Hartman, M Rahman, R Hwaiz, E Zhang… - Gastroenterology, 2015 - Elsevier
Background & Aims Neutrophils are involved in the development of acute pancreatitis (AP),
but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting …

Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma

L Zheng, J Xue, EM Jaffee, A Habtezion - Gastroenterology, 2013 - Elsevier
Immune cells are important in the pathogenesis of acute pancreatitis and determine disease
severity. Results from cytokine-based clinical trials for acute pancreatitis have been …

Acute pancreatitis: bench to the bedside

SJ Pandol, AK Saluja, CW Imrie, PA Banks - Gastroenterology, 2007 - gastrojournal.org
Acute pancreatitis is an acute inflammatory process of the pancreas that frequently involves
peripancreatic tissues and at times remote organ systems. The severity of the disease varies …

[HTML][HTML] Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

M Leppkes, C Maueröder, S Hirth, S Nowecki… - Nature …, 2016 - nature.com
Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the
nature of the primary occluding agents has remained elusive. Neutrophils make use of …

Inflammation in acute and chronic pancreatitis

A Habtezion - Current opinion in gastroenterology, 2015 - journals.lww.com
Inflammation in acute and chronic pancreatitis : Current Opinion in Gastroenterology
Inflammation in acute and chronic pancreatitis : Current Opinion in Gastroenterology Log in or …