Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

Wnt signaling and its bone tissue–specific inhibitor sclerostin are key regulators of bone
homeostasis. The therapeutic potential of anti-sclerostin antibodies (Scl-Abs), for bone mass …

Osteoporotic bones have reduced spongy bone mass, altered bone architecture, and
increased marrow fat. Bone marrow stem cells from osteoporotic patients are more likely to …

Osteoporosis is an important age-related bone disease characterized by increased bone
turnover with insufficient bone formation relative to bone resorption. According to the current …

Wnt5a is a representative ligand that activates the β‐catenin‐independent pathways.
Because the β‐catenin‐independent pathway includes multiple signalling cascades in …

The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …

Bone is a dynamic tissue that is constantly renewed by the coordinated action of two cell
types, ie., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in …

Mesenchymal stem cells (MSCs) arise from a variety of tissues, including bone marrow and
adipose tissue and, accordingly, have the potential to differentiate into multiple cell types …

Obesity and related disorders are a burgeoning public health epidemic, particularly in the
US Currently 34% of the US population is clinically obese (BMI> 30) and 68% are …

Chronic diseases account for approximately 45% of all deaths in developed countries and
are particularly prevalent in countries with the most sophisticated and robust public health …