Markov (state) models (MSMs) and related models of molecular kinetics have recently
received a surge of interest as they can systematically reconcile simulation data from either …

The intriguing process of protein folding comprises discrete steps that stabilize the protein
molecules in different conformations. The metastable state of protein is represented by …

Finding a low dimensional representation of data from long-timescale trajectories of
biomolecular processes, such as protein folding or ligand–receptor binding, is of …

We develop an approach to characterize the effects of gating by a multiconformation protein
consisting of macrostate conformations that are either accessible or inaccessible to ligand …

In the model organism Escherichia coli and related species, the general stress response
relies on tight regulation of the intracellular levels of the promoter specificity subunit RpoS …

Multistep phosphorelay (MSP) cascades mediate responses to a wide spectrum of stimuli,
including plant hormonal signaling, but several aspects of MSP await elucidation. Here, we …

反应调节蛋白是细菌双组分信号转导系统的重要组分, 用于传递来自组氨酸激酶的信号并产生
适应性反应. 在整个信号转导过程中, 反应调节蛋白的磷酸化和去磷酸化最终决定了该系统的 …

Nanopore DNA sequencing is a well-established technology that has accelerated
advancements in many fields, including medical research. Over the years, research has …

Multistep phosphorelay (MSP) cascades mediate responses to a wide spectrum of stimuli,
including plant hormonal signaling, but several aspects of MSP await elucidation. Here, we …