Small-angle scattering (SAS) of x-rays and neutrons is a fundamental tool in the study of
biological macromolecules. The major advantage of the method lies in its ability to provide …

Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …

The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …

Abstract Background The 16S rRNA gene is used extensively in bacterial phylogenetics, in
species delineation, and now widely in microbiome studies. However, the gene suffers from …

Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections
for the past half century. Whereas the interest in these versatile antibiotics continues to be …

Valuable information on translation initiation is available from biochemical data and recently
solved structures. We present a detailed description of current knowledge about the …

▪ Abstract The underlying basis for the accuracy of protein synthesis has been the subject of
over four decades of investigation. Recent biochemical and structural data make it possible …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

▪ Abstract The OB-fold domain is a compact structural motif frequently used for nucleic acid
recognition. Structural comparison of all OB-fold/nucleic acid complexes solved to date …

Translation, the decoding of mRNA into protein, is the third and final element of the central
dogma. The ribosome, a nucleoprotein particle, is responsible and essential for this process …