Dental caries is a chronic infectious disease resulting from the penetration of oral bacteria
into the enamel and dentin. Microorganisms subsequently trigger inflammatory responses in …

Background and Objective Pulpitis is mainly caused by an opportunistic infection of the pulp
space with commensal oral microorganisms. Depending on the state of inflammation …

Background Inflammatory biomarkers are potentially useful targets for pulpal diagnostic tests
that can identify pulp status and predict vital pulp treatment (VPT) outcome, however, their …

In the oral and maxillofacial region, the treatment of severe bone defects, caused by
fractures, cancers, congenital abnormalities, etc., remains a great challenge. In addition …

Regenerative endodontics (RE) therapy means physiologically replacing damaged pulp
tissue and regaining functional dentin–pulp complex. Current clinical RE procedures recruit …

Stem cells are essential for tissue homeostasis and regeneration throughout the lifespan of
multicellular organisms. The decline in stem cell function during advanced age is associated …

Concerns over the cost and destructive nature of dental treatment have led to the call for
novel minimally invasive, biologically based restorative solutions. For patients with …

Undifferentiated, highly proliferative, clonogenic, and self-renewing dental stem cells have
paved the way for novel approaches to mending cleft palates, rebuilding lost jawbone and …

MicroRNA (miRNA) is small RNA of 20 to 22 nucleotides in length and is stably present in
plasma. Regulating the expression of miRNA taken into cells has been suggested as a …

Introduction The improvement of regenerative endodontic procedures requires an
understanding of the key clinical questions combined with a fundamental biological …