[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches
Abstract The United States is in the midst of an opioid addiction and overdose crisis
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …
An overview of translationally informed treatments for posttraumatic stress disorder: animal models of Pavlovian fear conditioning to human clinical trials
ME Bowers, KJ Ressler - Biological psychiatry, 2015 - Elsevier
Posttraumatic stress disorder manifests after exposure to a traumatic event and is
characterized by avoidance/numbing, intrusive symptoms and flashbacks, mood and …
characterized by avoidance/numbing, intrusive symptoms and flashbacks, mood and …
Stress and opioids: role of opioids in modulating stress-related behavior and effect of stress on morphine conditioned place preference
Research studies have defined the important role of endogenous opioids in modulating
stress-associated behavior. The release of β-endorphins in the amygdala in response to …
stress-associated behavior. The release of β-endorphins in the amygdala in response to …
Targeting opioid dysregulation in depression for the development of novel therapeutics
CA Browne, I Lucki - Pharmacology & therapeutics, 2019 - Elsevier
Since the serendipitous discovery of the first class of modern antidepressants in the 1950's,
all pharmacotherapies approved by the Food and Drug Administration for major depressive …
all pharmacotherapies approved by the Food and Drug Administration for major depressive …
Threat response system: parallel brain processes in pain vis-à-vis fear and anxiety
I Elman, D Borsook - Frontiers in psychiatry, 2018 - frontiersin.org
Pain is essential for avoidance of tissue damage and for promotion of healing.
Notwithstanding the survival value, pain brings about emotional suffering reflected in fear …
Notwithstanding the survival value, pain brings about emotional suffering reflected in fear …
The endogenous opioid system: role and dysfunction caused by opioid therapy
T Toubia, T Khalife - Clinical obstetrics and gynecology, 2019 - journals.lww.com
The endogenous opioid system is comprised of a wide array of receptors and ligands that
are present throughout the central and peripheral nervous system, the gastrointestinal tract …
are present throughout the central and peripheral nervous system, the gastrointestinal tract …
The role of brain interleukin-1 in stress-enhanced fear learning
ME Jones, CL Lebonville, D Barrus… - …, 2015 - nature.com
Posttraumatic stress disorder (PTSD) has been shown to be associated with pro-
inflammatory markers, including elevated plasma levels of interleukin-1β (IL-1β). However …
inflammatory markers, including elevated plasma levels of interleukin-1β (IL-1β). However …
Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β
ME Jones, CL Lebonville, JE Paniccia… - Brain, Behavior, and …, 2018 - Elsevier
Post-traumatic stress disorder (PTSD) is associated with immune dysregulation. We have
previously shown that severe stress exposure in a preclinical animal model of the disorder …
previously shown that severe stress exposure in a preclinical animal model of the disorder …
Chemogenetic manipulation of dorsal hippocampal astrocytes protects against the development of stress-enhanced fear learning
Maladaptive behavioral outcomes following stress have been associated with immune
dysregulation. For example, we have previously reported that stress-induced dorsal …
dysregulation. For example, we have previously reported that stress-induced dorsal …