Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …

A novel series of hybrid molecules were designed and synthesized by fusing the
pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as …

Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …

Alzheimer's disease (AD) is one of the most prevalent geriatric diseases and a significant
cause of high mortality. This crippling disorder is becoming more prevalent at an …

Alzheimer's disease is debilitating neurodegenerative disorder in the elderly. Current
therapy relies on administration of acetylcholinesterase inhibitors (AChEIs)-donepezil …

Multi-target-directed ligands (MTDLs) centered on β-secretase 1 (BACE-1) inhibition are
emerging as innovative therapeutics in addressing the complexity of neurodegenerative …

A novel family of donepezil–ferulic acid hybrids were designed, synthesized and biologically
evaluated as multi-target-directed ligands against Alzheimer's disease by fusing a fragment …

In this protocol, a series of 3-benzyloxyflavone derivatives have been designed,
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …

Dihydro-5, 6-dimethoxy-2-[4-(4-alkyl-4-methylpiperazinium-1-yl) benzylidine]-1H-inden-1-
one halide salt derivatives as a novel donepezil hybrid analogs with the property of …