The Philadelphia chromosome in leukemogenesis
ZJ Kang, YF Liu, LZ Xu, ZJ Long, D Huang… - Chinese journal of …, 2016 - Springer
The truncated chromosome 22 that results from the reciprocal translocation t (9; 22)(q34;
q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid …
q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid …
Mechanisms of disease progression and resistance to tyrosine kinase inhibitor therapy in chronic myeloid leukemia: an update
Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …
IKZF1 status as a prognostic feature in BCR-ABL1–positive childhood ALL
A Van Der Veer, M Zaliova, F Mottadelli… - Blood, The Journal …, 2014 - ashpublications.org
Childhood BCR-ABL1–positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
has an unfavorable outcome and shows high frequency of IKZF1 deletions. The prognostic …
has an unfavorable outcome and shows high frequency of IKZF1 deletions. The prognostic …
An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia
Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic
phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) …
phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) …
Does BCR/ABL1 positive Acute Myeloid Leukaemia Exist?
EP Nacheva, CD Grace, D Brazma… - British journal of …, 2013 - Wiley Online Library
The BCR/ABL 1 fusion gene, usually carried by the P hiladelphia chromosome (P h)
resulting from t (9; 22)(q34; q11) or variants, is pathognomonic for chronic myeloid …
resulting from t (9; 22)(q34; q11) or variants, is pathognomonic for chronic myeloid …
Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
R Peng, PF Zhang, X Yang, CY Wei, XY Huang… - Journal of Experimental …, 2019 - Springer
Background RING finger protein 38 (RNF38), a member of the RNF protein family, has just
emerged as a vital driver of cancer progression. However, the oncogenic mechanisms of …
emerged as a vital driver of cancer progression. However, the oncogenic mechanisms of …
BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features
NR Neuendorff, T Burmeister, B Dörken… - Annals of …, 2016 - Springer
BCR-ABL-positive acute myeloid leukemia (AML) is a rare subtype of AML that is now
included as a provisional entity in the 2016 revised WHO classification of myeloid …
included as a provisional entity in the 2016 revised WHO classification of myeloid …
Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic myeloid leukemia
Blast crisis of chronic myeloid leukemia is associated with poor survival and the
accumulation of genomic lesions. Using whole-exome and/or RNA sequencing of patients at …
accumulation of genomic lesions. Using whole-exome and/or RNA sequencing of patients at …
The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression
LC Young, MJ Hendzel - Biochemistry and cell biology, 2013 - cdnsciencepub.com
The Jumonji D2 proteins (JMJD2/KDM4) function to demethylate di-and trimethylated
(me2/3) histone 3 lysine 9 (H3K9me2/3) and H3K36me3. Knockout mouse models for …
(me2/3) histone 3 lysine 9 (H3K9me2/3) and H3K36me3. Knockout mouse models for …
Ikaros and leukaemia
L Olsson, B Johansson - British journal of haematology, 2015 - Wiley Online Library
The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …