The 2013 discovery of Telomerase reverse transcriptase (TERT) promoter mutations chr5,
1,295,228 C> T (C228T) and 1,295,250 C> T (C250T) in thyroid cancer represents an …

Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Context Little is known about the frequency of key mutations in thyroid cancer metastases
and its relationship with the primary tumor genotype. Objectives To evaluate the frequency of …

Thyroid cancer continues to be the most common malignancy of endocrine glands. The
incidence of thyroid cancer has risen significantly over the past 4 decades and has emerged …

Telomerase reverse transcriptase (TERT) promoter mutation has been reported to be
associated with aggressive characteristics in differentiated thyroid cancer (DTC). This study …

Evasion of replicative senescence and proliferation without restriction, sometimes
designated as immortalisation, is one of the hallmarks of cancer that may be attained …

Background The association between telomerase reverse transcriptase (TERT) promoter
mutations and some clinical behaviors in thyroid cancer remains controversial and requires …

Papillary thyroid carcinoma (PTC), the most common malignancy of the endocrine system, is
frequently driven by BRAF V600E mutation, which was reported in 35–60% cases in …