Developing efficient and safe adjuvants for use in human vaccines remains both a challenge
and a necessity. Past approaches have been largely empirical and generally used a single …

Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to
develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed …

Background Malaria in pregnancy can expose the fetus to malaria-infected erythrocytes or
their soluble products, thereby stimulating T and B cell immune responses to malaria blood …

Secretion of microneme proteins is essential to Plasmodium invasion but the molecular
composition of these secretory organelles remains poorly defined. Here, we describe the …

A central goal in vaccinology is the induction of high and sustained Ab responses. Protein-in-
adjuvant formulations are commonly used to achieve such responses. However, their …

Considerable efforts and funding are available to shift from laboratory experiments to field
trials. Field trials remain the definitive method to assess the real impact of different vaccines …

The present study was conducted to investigate the immunoenhancing effects of
Montanide™ ISA 71 VG adjuvant on profilin subunit antigen vaccination. Broiler chickens …

Plasmodium falciparum blood-stage antigens such as merozoite surface protein 1 (MSP-1),
apical membrane antigen 1 (AMA-1), and the 175-kDa erythrocyte binding antigen (EBA …

Protection against malaria through vaccination is known to be achievable, as first
demonstrated over 30 years ago. Vaccination via repeated bites with Plasmodium …

A fusion chimeric vaccine comprising multiple protective domains of different blood-stage
Plasmodium falciparum antigens is perhaps necessary for widening the protective immune …