Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

Long non-coding RNAs (lncRNAs) were, once, viewed as “noise” for transcription. Recently,
many lncRNAs are functionally linked to several human disorders, including cancer. Coiled …

Telomere dysfunction causes chromosomal instability which is associated with many
cancers and age-related diseases. The non-coding telomeric repeat-containing RNA …

We review the most well characterized long non‐coding RNAs (lncRNAs) with important
roles in hallmarks of cancer, additionally including lncRNAs with a higher potential for …

Cancer is one of the most common causes of death; in parallel, the incidence and
prevalence of central nervous system diseases are equally high. Among neurodegenerative …

Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-
dependent intricate biological process characterised by the cumulative decline in the …

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that
confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 …

Aging is progressive physiological degeneration and consequently declined function, which
is linked to senescence on both cellular and organ levels. Accumulating studies indicate that …

Ever since their discovery, the telomeres and the telomerase have been topics of intensive
research, first as a mechanism of cellular aging and later as an indicator of health and …

The telomere protects against genomic instability by minimizing the accelerated end
resection of the genetic material, a phenomenon that results in severe chromosome …