The clinical success of immune checkpoint inhibitors has highlighted the central role of the
immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer …

Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides
TGF-β and IL-35. It is produced by activated immune cells, in particular monocytes …

Psoriasis is a common T-cell-mediated skin disease with 2–3% prevalence worldwide.
Psoriasis is considered to be an autoimmune disease, but the precise nature of the …

Natural killer (NK) cell therapies have emerged as a potential therapeutic approach to
various cancers. Their efficacy, however, is limited by their low persistence and anergy …

Several preclinical studies demonstrate that antitumor efficacy of programmed cell death-1
(PD-1)/programmed death-ligand 1 (PD-L1) blockade can be improved by combination with …

Innate immune cells, particularly macrophages and epithelial cells, play a key role in
multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL …

Inflammation is a disease of vigorous uncontrolled activated immune responses.
Overwhelming reports have suggested that the modulation of immune responses by …

Daratumumab (Dara), a multiple myeloma (MM) therapy, is an antibody against the surface
receptor CD38, which is expressed not only on plasma cells but also on NK cells and …

Ectopic expression of transcription factors has been used to reprogram differentiated
somatic cells toward pluripotency or to directly reprogram them to other somatic cell …

Current immunotherapies provide limited benefits against T cell-depleted tumors, calling for
therapeutic innovation. Using multi-omics integration of cancer patient data, we predict a …