Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases
Y Wang, M Zhao, S Liu, J Guo, Y Lu, J Cheng… - Cell death & …, 2020 - nature.com
Macrophages (Mφ) are primary innate immune cells that exhibit diverse functions in
response to different pathogens or stimuli, and they are extensively involved in the …
response to different pathogens or stimuli, and they are extensively involved in the …
Exosomes and other extracellular vesicles in host–pathogen interactions
An effective immune response requires the engagement of host receptors by pathogen‐
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …
Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and beiging in white adipose tissue
H Zhao, Q Shang, Z Pan, Y Bai, Z Li, H Zhang… - Diabetes, 2018 - Am Diabetes Assoc
Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated
inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects in …
inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects in …
Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain
Recent work has stimulated interest in the use of exosomes as nanocarriers for delivery of
small drugs, RNAs, and proteins to the central nervous system (CNS). To overcome the …
small drugs, RNAs, and proteins to the central nervous system (CNS). To overcome the …
Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo
L Bouchareychas, P Duong, S Covarrubias, E Alsop… - Cell reports, 2020 - cell.com
Developing strategies that promote the resolution of vascular inflammation and
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …
Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …
cell types and participate in physiological and pathophysiological processes. EVs mediate …
Biological properties of extracellular vesicles and their physiological functions
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …
Exosomes as critical agents of cardiac regeneration triggered by cell therapy
The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be
possible to regenerate injured heart muscle previously thought to be permanently scarred …
possible to regenerate injured heart muscle previously thought to be permanently scarred …
Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen
A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …
remains one of the leading causes of mortality across the world. There is an urgent …
Extracellular vesicles as next generation immunotherapeutics
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …