Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases

Y Wang, M Zhao, S Liu, J Guo, Y Lu, J Cheng… - Cell death & …, 2020 - nature.com
Macrophages (Mφ) are primary innate immune cells that exhibit diverse functions in
response to different pathogens or stimuli, and they are extensively involved in the …

Exosomes and other extracellular vesicles in host–pathogen interactions

JS Schorey, Y Cheng, PP Singh, VL Smith - EMBO reports, 2015 - embopress.org
An effective immune response requires the engagement of host receptors by pathogen‐
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …

Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and beiging in white adipose tissue

H Zhao, Q Shang, Z Pan, Y Bai, Z Li, H Zhang… - Diabetes, 2018 - Am Diabetes Assoc
Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated
inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects in …

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

D Yuan, Y Zhao, WA Banks, KM Bullock, M Haney… - Biomaterials, 2017 - Elsevier
Recent work has stimulated interest in the use of exosomes as nanocarriers for delivery of
small drugs, RNAs, and proteins to the central nervous system (CNS). To overcome the …

Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo

L Bouchareychas, P Duong, S Covarrubias, E Alsop… - Cell reports, 2020 - cell.com
Developing strategies that promote the resolution of vascular inflammation and
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Exosomes as critical agents of cardiac regeneration triggered by cell therapy

AGE Ibrahim, K Cheng, E Marbán - Stem cell reports, 2014 - cell.com
The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be
possible to regenerate injured heart muscle previously thought to be permanently scarred …

Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen

A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …