[HTML][HTML] The iron tug-of-war between bacterial siderophores and innate immunity
Iron is necessary for the survival of almost all aerobic organisms. In the mammalian host,
iron is a required cofactor for the assembly of functional iron-sulfur (Fe-S) cluster proteins …
iron is a required cofactor for the assembly of functional iron-sulfur (Fe-S) cluster proteins …
Advances in the study of subclinical AKI biomarkers
C Zou, C Wang, L Lu - Frontiers in Physiology, 2022 - frontiersin.org
Acute kidney injury (AKI) is a prevalent and serious illness in all clinical departments, with a
high morbidity and death rate, particularly in intensive care units, where prevention and …
high morbidity and death rate, particularly in intensive care units, where prevention and …
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
Structures of LRP2 reveal a molecular machine for endocytosis
The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …
Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
B Olson, X Zhu, MA Norgard, PR Levasseur… - Nature …, 2021 - nature.com
Abstract Lipocalin 2 (LCN2) was recently identified as an endogenous ligand of the type 4
melanocortin receptor (MC4R), a critical regulator of appetite. However, it remains unknown …
melanocortin receptor (MC4R), a critical regulator of appetite. However, it remains unknown …
Lipocalin 2: an emerging player in iron homeostasis and inflammation
Lipocalin 2 (Lcn2), an innate immune protein, has emerged as a critical iron regulatory
protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 …
protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 …
Lipocalin 2 receptors: facts, fictions, and myths
SK Schröder, N Gasterich, S Weiskirchen… - Frontiers in …, 2023 - frontiersin.org
The human 25-kDa Lipocalin 2 (LCN2) was first identified and purified as a protein that in
part is associated with gelatinase from neutrophils. This protein shows a high degree of …
part is associated with gelatinase from neutrophils. This protein shows a high degree of …
Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
Inflammatory bowel disease is associated with changes in the mucosal barrier, increased
intestinal permeability, and increased risk of infections and sepsis, but the underlying …
intestinal permeability, and increased risk of infections and sepsis, but the underlying …
Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature
D Lim, J Jeong, J Song - CNS neuroscience & therapeutics, 2021 - Wiley Online Library
Dementia accompanied by memory loss is considered one of the most common
neurodegenerative diseases worldwide, and its prevalence is gradually increasing. Known …
neurodegenerative diseases worldwide, and its prevalence is gradually increasing. Known …
REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis
Y Xia, G Ge, H Xiao, M Wu, T Wang, C Gu… - Cell Death & …, 2023 - nature.com
Osteoporosis is not well treated due to the difficulty of finding commonalities between the
various types of it. Iron homeostasis is a vital component in supporting biochemical …
various types of it. Iron homeostasis is a vital component in supporting biochemical …