Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …

A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is
a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell …

There are a variety of medical conditions associated with chronic sinonasal inflammation,
including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided …

The interaction between respiratory pathogens and their hosts is complex and incompletely
understood. This is particularly true when pathogens encounter the mucus layer covering …

The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of influenza A virus are
responsible for the surface interactions of the virion with the host. Entry of the virus is …

Abstract Background Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias)
from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release …

The mucosa of the gastrointestinal tract, eyes, nose, lungs, cervix and vagina is lined by
epithelium interspersed with mucus-secreting goblet cells, all of which contribute to their …

In 2019, a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) was identified as the causative agent of Coronavirus Disease 2019 (COVID …