Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …

Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Behavioural, cellular and molecular studies have revealed significant effects of enriched
environments on rodents and other species, and provided new insights into mechanisms of …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, cognitive and psychiatric manifestations. Since the mutation …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an
expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and …

Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's
disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a …

Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the
gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein …