Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …

Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Mitochondria are multifunctional organelles that not only produce energy for the cell, but are
also important for cell signalling, apoptosis and many biosynthetic pathways. In most cell …

To maintain homeostasis, every cell must constantly monitor its energy level and
appropriately adjust energy, in the form of ATP, production rates based on metabolic …

Mitochondria play an essential role in bioenergetics and respiratory functions for cell viability
through numerous biochemical processes. To maintain mitochondria quality control and …

Intellectual disability (ID) is a common morbid condition with a wide range of etiologies. The
list of monogenic forms of ID has increased rapidly in recent years thanks to the …

Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked
seizures that emerge after a latent period of epileptogenesis. These epilepsies pose a major …

Neurons are particularly vulnerable to mitochondrial dysfunction due to high energy demand
and an inability to proliferate. Therefore, dysfunctional mitochondria cause various …