Stealth nanoparticles in oncology: Facing the PEG dilemma

S Zalba, TLM Ten Hagen, C Burgui… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (Nps) have revolutionized the landscape of many treatments, by modifying not
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …

PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective

R Tenchov, JM Sasso, QA Zhou - Bioconjugate chemistry, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

JS Suk, Q Xu, N Kim, J Hanes, LM Ensign - Advanced drug delivery reviews, 2016 - Elsevier
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …

Polyethylene glycol immunogenicity: theoretical, clinical, and practical aspects of anti-polyethylene glycol antibodies

BM Chen, TL Cheng, SR Roffler - ACS nano, 2021 - ACS Publications
Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached
to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance …

PEGylated liposomes: immunological responses

M Mohamed, AS Abu Lila, T Shimizu… - … and Technology of …, 2019 - Taylor & Francis
ABSTRACT A commonly held view is that nanocarriers conjugated to polyethylene glycol
(PEG) are non-immunogenic. However, many studies have reported that unexpected …

Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration

Z Zhou, X Liu, D Zhu, Y Wang, Z Zhang, X Zhou… - Advanced drug delivery …, 2017 - Elsevier
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Drug delivery systems, CNS protection, and the blood brain barrier

RK Upadhyay - BioMed research international, 2014 - Wiley Online Library
Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …

Extracellular vesicles as an efficient and versatile system for drug delivery

XTT Dang, JM Kavishka, DX Zhang, M Pirisinu, MTN Le - Cells, 2020 - mdpi.com
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …

Bioinert, stealth or interactive: how surface chemistry of nanocarriers determines their fate in vivo

JD Friedl, V Nele, G De Rosa… - Advanced functional …, 2021 - Wiley Online Library
Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote
drug transport across membranes, to protect their payload from premature degradation, and …