Stealth nanoparticles in oncology: Facing the PEG dilemma
S Zalba, TLM Ten Hagen, C Burgui… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (Nps) have revolutionized the landscape of many treatments, by modifying not
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …
PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …
commonly used approach for improving the efficiency of drug and gene delivery to target …
Polyethylene glycol immunogenicity: theoretical, clinical, and practical aspects of anti-polyethylene glycol antibodies
BM Chen, TL Cheng, SR Roffler - ACS nano, 2021 - ACS Publications
Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached
to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance …
to peptides, proteins, nucleic acids, liposomes, and nanoparticles to reduce renal clearance …
PEGylated liposomes: immunological responses
M Mohamed, AS Abu Lila, T Shimizu… - … and Technology of …, 2019 - Taylor & Francis
ABSTRACT A commonly held view is that nanocarriers conjugated to polyethylene glycol
(PEG) are non-immunogenic. However, many studies have reported that unexpected …
(PEG) are non-immunogenic. However, many studies have reported that unexpected …
Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
Polymeric Nanoparticles for Drug Delivery
MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
Drug delivery systems, CNS protection, and the blood brain barrier
RK Upadhyay - BioMed research international, 2014 - Wiley Online Library
Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …
Extracellular vesicles as an efficient and versatile system for drug delivery
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …
not been successfully translated into clinical applications. One of the major factors hindering …
Bioinert, stealth or interactive: how surface chemistry of nanocarriers determines their fate in vivo
Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote
drug transport across membranes, to protect their payload from premature degradation, and …
drug transport across membranes, to protect their payload from premature degradation, and …