Tailoring nanomaterials for targeting tumor‐associated macrophages

M Ovais, M Guo, C Chen - Advanced materials, 2019 - Wiley Online Library
Advances in the field of nanotechnology together with an increase understanding of tumor
immunology have paved the way for the development of more personalized cancer immuno …

Progress on modulating tumor‐associated macrophages with biomaterials

M Sylvestre, CA Crane, SH Pun - Advanced Materials, 2020 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are a complex and heterogeneous population of
cells within the tumor microenvironment. In many tumor types, TAMs contribute toward tumor …

The promising role of tumor-associated macrophages in the treatment of cancer

H Wang, X Wang, X Zhang, W Xu - Drug Resistance Updates, 2024 - Elsevier
Macrophages are important components of the immune system. Mature macrophages can
be recruited to tumor microenvironment that affect tumor cell proliferation, invasion and …

Nanomaterials targeting tumor associated macrophages for cancer immunotherapy

C Zhao, X Pang, Z Yang, S Wang, H Deng… - Journal of Controlled …, 2022 - Elsevier
Tumor-associated macrophages (TAMs) play an important role in regulating tumor growth,
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …

[HTML][HTML] Development of functional nanomedicines for tumor associated macrophages-focused cancer immunotherapy

X Wei, J Wang, M Liang, M Song - Theranostics, 2022 - ncbi.nlm.nih.gov
Clinical cancer immunotherapies are usually impeded by tumor immunosuppression driven
by tumor associated macrophages (TAMs). Thus, TAMs can be considered as a promising …

Leveraging macrophages for cancer theranostics

L Liu, H Li, J Wang, J Zhang, XJ Liang, W Guo… - Advanced drug delivery …, 2022 - Elsevier
As fundamental immune cells in innate and adaptive immunity, macrophages engage in a
double-edged relationship with cancer. Dissecting the character of macrophages in cancer …

Functionalized nanoparticles targeting tumor-associated macrophages as cancer therapy

Y He, RF de Araújo Júnior, LJ Cruz, C Eich - Pharmaceutics, 2021 - mdpi.com
The tumor microenvironment (TME) plays a central role in regulating antitumor immune
responses. As an important part of the TME, alternatively activated type 2 (M2) macrophages …

Targeted delivery of zoledronate to tumor-associated macrophages for cancer immunotherapy

X Zang, X Zhang, H Hu, M Qiao, X Zhao… - Molecular …, 2019 - ACS Publications
Tumor-associated macrophages (TAMs) are recruited from circulatory monocytes by tumor-
derived factors, which differentiate into macrophages residing in the tumor …

Nanomedicine-based cancer immunotherapies developed by reprogramming tumor-associated macrophages

X Li, X Guo, J Ling, Z Tang, G Huang, L He, T Chen - Nanoscale, 2021 - pubs.rsc.org
Tumor microenvironment is a complex ecosystem composed of tumor extracellular matrix,
fibroblasts, blood vessels, and immune cells, promoting tumor development by secreting …

Normalization of the tumor microvasculature based on targeting and modulation of the tumor microenvironment

Z Li, F Ning, C Wang, H Yu, Q Ma, Y Sun - Nanoscale, 2021 - pubs.rsc.org
Angiogenesis is an essential process for tumor development. Owing to the imbalance
between pro-and anti-angiogenic factors, the tumor vasculature possesses the …