There has been an escalation in reports over the last decade examining the efficacy of bone
marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of
the total organic component of bone matrix. However, the precise cellular origin and …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

Bone stroma contributes to the regulation of osteogenesis and hematopoiesis but also to
fracture healing and disease processes. Mesenchymal stromal cells from bone (BMSCs) …

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …

Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

Developmental osteogenesis, physiological bone remodelling and fracture healing require
removal of matrix and cellular debris. Osteoclasts generated by the fusion of circulating …

Abstract Purpose of Review The periosteum, the outer layer of bone, is a major source of
skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on …

The outer coverings of the skeleton, which is also known as the periosteum, are arranged in
concentric layers and act as a reservoir for tissue-specific bone progenitors. The cellular …