Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes

T Nemkov, D Stephenson, EJ Earley, GR Keele, A Hay… - Cell Metabolism, 2024 - cell.com
Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …

Extended supercooled storage of red blood cells

Z Isiksacan, N William, R Senturk, L Boudreau… - Communications …, 2024 - nature.com
Red blood cell (RBC) transfusions facilitate many life-saving acute and chronic
interventions. Transfusions are enabled through the gold-standard hypothermic storage of …

Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport

TJ Wise, ME Ott, MS Joseph, IJ Welsby… - Frontiers in …, 2024 - frontiersin.org
Efficient distribution of oxygen (O2) to the tissues in mammals depends on the evolved
ability of red blood cell (RBC) hemoglobin (Hb) to sense not only O2 levels, but metabolic …

Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion

L Kaestner, P Schlenke… - Proceedings of the …, 2024 - National Acad Sciences
Recently, Isiksacan et al. introduced in their perspective article the assessment of stored red
blood cells (RBCs) through lab-ona-chip (LOC) technologies for precision transfusion …

Red blood cell transfusion-related dynamics of extracellular vesicles in intensive care patients: a prospective subanalysis

P Raeven, K Karlhofer, LS Sztulman, J Brugger… - Scientific Reports, 2024 - nature.com
Extracellular vesicles (EVs) accumulate during packed red blood cell (PRBC) storage. To
date, the involvement of EVs in transfusion-related immunomodulation (TRIM) has not been …

Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine

Z Isiksacan, A D'Alessandro… - Proceedings of the …, 2024 - National Acad Sciences
In a recent Perspective, we emphasized the lack of translatable tools to objectively assess
the quality of stored red blood cells (RBC) for “real age” determination of stored units and …

Advances in Red Blood Cells Research

A Bogdanova, L Kaestner - Cells, 2024 - mdpi.com
This Editorial 'Advances in Red Blood Cell Research'is the preface for the special issue with
the same title which files 14 contributions listed in Table 1. This collection of articles …

[HTML][HTML] Elevated mtDNA content in RBCs promotes oxidative stress may be responsible for faster senescence in men

W Zhou, X Xu, D Qi, X Zhang, F Zheng - Archives of Gerontology and …, 2024 - Elsevier
Background Both we and others have found that RBC counts are significantly lower in older
compared to younger. However, when gender is factored in, a significant age-related …

Facile compliance-based pump for blood physiometer

YJ Kang - Physics of Fluids, 2024 - pubs.aip.org
The biomechanical properties of blood are considered promising label-free biomarkers for
early disease detection. Disposable pumps have been suggested as replacements for bulky …

[HTML][HTML] Thromboelastogram and coagulation function index: relevance for female breast cancer

Q Peng, J Zhu, X Ren - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
Objective Thromboelastogram (TEG), routine platelet (PLT) count, and the coagulation
function indicators in patients with different breast diseases were determined and analyzed …