[HTML][HTML] Recent developments in lactose blend formulations for carrier-based dry powder inhalation

GA Hebbink, M Jaspers, HJW Peters… - Advanced Drug Delivery …, 2022 - Elsevier
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI)
formulations. Numerous inhalation therapies have been developed using lactose as a …

[HTML][HTML] A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases

S He, J Gui, K Xiong, M Chen, H Gao, Y Fu - Journal of nanobiotechnology, 2022 - Springer
Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung
diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass …

The future of dry powder inhaled therapy: Promising or discouraging for systemic disorders?

Y Ye, Y Ma, J Zhu - International journal of pharmaceutics, 2022 - Elsevier
Dry powder inhalation therapy has been shown to be an effective method for treating
respiratory diseases like asthma, Chronic Obstructive Pulmonary Diseases and Cystic …

Pulmonary drug delivery for acute respiratory distress syndrome

Q Fei, I Bentley, SN Ghadiali, JA Englert - Pulmonary Pharmacology & …, 2023 - Elsevier
The acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes
respiratory failure. Despite numerous clinical trials, there are no molecularly targeted …

[HTML][HTML] Understanding the importance of capsules in dry powder inhalers

F Buttini, E Quarta, C Allegrini, F Lavorini - Pharmaceutics, 2021 - mdpi.com
Pulmonary drug delivery is currently the focus of research and development because of its
potential to produce maximum therapeutic benefit to patients by directing the drug straight to …

Scientific and regulatory activities initiated by the US Food and Drug Administration to foster approvals of generic dry powder inhalers: quality perspective

N El-Gendy, CM Bertha, M Abd El-Shafy… - Advanced Drug Delivery …, 2022 - Elsevier
Regulatory science for generic dry powder inhalation products worldwide has evolved over
the last decade. The revised draft guidance Metered Dose Inhaler (MDI) and Dry Powder …

A quality-by-design strategic approach for the development of bedaquiline-pretomanid nanoparticles as inhalable dry powders for TB treatment

SM Patil, AM Diorio, P Kommarajula… - International Journal of …, 2024 - Elsevier
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (M. tb) and is the second
leading cause of death from an infectious disease globally. The disease mainly affects the …

[HTML][HTML] Effect of different molecular weights of polyethylene glycol as a plasticizer on the formulation of dry powder inhaler capsules: Investigation of puncturing size …

RR Kalmer, A Karimi, M Golizadeh… - Arabian Journal of …, 2022 - Elsevier
Today, the principle of research and development is pulmonary drug delivery due to the
potential for maximizing therapeutic effects for patients by direct drug targeting the pathology …

Recent advances in orthogonal analytical techniques for microstructural understanding of inhalable particles: present status and future perspective

P Jadhav, P Patil, D Bhagwat, V Gaikwad… - Journal of Drug Delivery …, 2022 - Elsevier
The quick advancement in pulmonary medicines, delivery mechanisms, and inhaler device
techniques in the last few years has recommended that the microstructural understanding of …

[HTML][HTML] The role of capsule aperture size on the dispersion of carrier-based formulation at different air flowrates

P Tang, M Kakhi, A Albariqi, SRB Behara… - International Journal of …, 2023 - Elsevier
The effect of capsule aperture size on the aerosol performance of lactose blend formulation
was studied using Foradil®(containing 12 μg of formoterol fumarate (FF 1) and 24 mg of …