Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

Next-generation sequencing technology has rapidly accelerated the discovery of genetic
variants of interest in individuals with rare diseases. However, showing that these variants …

Background DYRK1A maps to the Down syndrome critical region at 21q22. Mutations in this
kinase-encoding gene have been reported to cause microcephaly associated with either …

Intellectual disability (ID) is a heterogeneous clinical entity and includes an excess of males
who harbor variants on the X-chromosome (XLID). We report rare FAM50A missense …

Although innate color preference of motile organisms may provide clues to behavioral
biases, it has remained a longstanding question. In this study, we investigated innate color …

Folding free energy is an important biophysical characteristic of proteins that reflects the
overall stability of the 3D structure of macromolecules. Changes in the amino acid …

Early-life exposure to toxicants could affect health outcomes in adulthood. We determined
the effects of early-life exposure to the organophosphorus flame-retardant tris (1, 3-dichloro …

Genetic variants in ZNF536 contribute to the risk for neuropsychiatric disorders such as
schizophrenia, autism, and others. The role of this putative transcriptional repressor in brain …

There is increasing recognition of the importance of early-life environmental exposures in
health disorders at later-life stages. The aim of this study was to evaluate whether early-life …

Pathogenic variants in the X‐linked gene ZC4H2, which encodes a zinc‐finger protein,
cause an infrequently described syndromic form of arthrogryposis multiplex congenita …