A critical overview of computational approaches employed for COVID-19 drug discovery
COVID-19 has resulted in huge numbers of infections and deaths worldwide and brought
the most severe disruptions to societies and economies since the Great Depression …
the most severe disruptions to societies and economies since the Great Depression …
Airborne transmission of COVID-19: aerosol dispersion, lung deposition, and virus-receptor interactions
Coronavirus disease 2019 (COVID-19), due to infection by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is now causing a global pandemic. Aerosol …
syndrome coronavirus 2 (SARS-CoV-2), is now causing a global pandemic. Aerosol …
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
INTRODUCTION Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism
Vaccination-based exposure to spike protein derived from early SARS-CoV-2 sequences is
the key public health strategy against COVID-19. Successive waves of SARS-CoV-2 …
the key public health strategy against COVID-19. Successive waves of SARS-CoV-2 …
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health
response to COVID-19. The emergence of hypermutated, increasingly transmissible variants …
response to COVID-19. The emergence of hypermutated, increasingly transmissible variants …
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models
HY Huang, HY Liao, X Chen, SW Wang… - Science Translational …, 2022 - science.org
A major challenge to end the pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
L Hanke, L Vidakovics Perez, DJ Sheward… - Nature …, 2020 - nature.com
SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and
the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction …
the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction …
Differential interactions between human ACE2 and spike RBD of SARS-CoV-2 variants of concern
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the current coronavirus disease 2019 (COVID-19) pandemic. It is known that the receptor …
the current coronavirus disease 2019 (COVID-19) pandemic. It is known that the receptor …
Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area
We sequenced the genomes of 5,085 severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) strains causing two coronavirus disease 2019 (COVID-19) disease waves in …
(SARS-CoV-2) strains causing two coronavirus disease 2019 (COVID-19) disease waves in …
Multifaceted computational modeling in glycoscience
S Perez, O Makshakova - Chemical Reviews, 2022 - ACS Publications
Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …