Molecular mechanisms and physiological importance of circadian rhythms

A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Mechanisms and mitochondrial redox signaling in photobiomodulation

MR Hamblin - Photochemistry and photobiology, 2018 - Wiley Online Library
Photobiomodulation (PBM) involves the use of red or near‐infrared light at low power
densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce …

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

L Zhou, Z Zhang, E Nice, C Huang, W Zhang… - Journal of Hematology & …, 2022 - Springer
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder

A Patke, PJ Murphy, OE Onat, AC Krieger, T Özçelik… - Cell, 2017 - cell.com
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes∼
24 hr rhythms in many behavioral and physiological processes. This system is altered in …

Molecular mechanism of the repressive phase of the mammalian circadian clock

X Cao, Y Yang, CP Selby, Z Liu… - Proceedings of the …, 2021 - National Acad Sciences
The mammalian circadian clock consists of a transcription–translation feedback loop (TTFL)
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …

Macromolecular assemblies of the mammalian circadian clock

RP Aryal, PB Kwak, AG Tamayo, M Gebert, PL Chiu… - Molecular cell, 2017 - cell.com
The mammalian circadian clock is built on a feedback loop in which PER and CRY proteins
repress their own transcription. We found that in mouse liver nuclei all three PERs, both …

Regulation of circadian clock transcriptional output by CLOCK: BMAL1

AJ Trott, JS Menet - PLoS genetics, 2018 - journals.plos.org
The mammalian circadian clock relies on the transcription factor CLOCK: BMAL1 to
coordinate the rhythmic expression of 15% of the transcriptome and control the daily …

Off the clock: from circadian disruption to metabolic disease

E Maury - International journal of molecular sciences, 2019 - mdpi.com
Circadian timekeeping allows appropriate temporal regulation of an organism's internal
metabolism to anticipate and respond to recurrent daily changes in the environment …

[HTML][HTML] The phosphorylation switch that regulates ticking of the circadian clock

R Narasimamurthy, DM Virshup - Molecular cell, 2021 - cell.com
Summary In our 24/7 well-lit world, it's easy to skip or delay sleep to work, study, and play.
However, our circadian rhythms are not easily fooled; the consequences of jet lag and shift …