The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

Top-down proteomics (TDP) aims to identify and profile intact protein forms (proteoforms)
extracted from biological samples. True proteoform characterization requires that both the …

Cellular adaptation to low-oxygen environments is mediated in part by the hypoxia-inducible
factors (HIFs). Like other transcription factors, the stability and transcriptional activity of HIFs …

Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is
essential to advance understanding of phosphorylation-mediated signaling events …

Post-translational modifications (PTMs) are ubiquitous and key to regulating protein function.
Understanding the dynamics of individual PTMs and their biological roles requires robust …

Natural compounds are an important class of potent drug molecules including some
retrospectively found to act as stabilizers of protein–protein interactions (PPIs). However, the …

Increasing evidence shows that many transcription factors execute important biologic
functions independent from their DNA-binding capacity. The NF-κB p65 (RELA) subunit is a …

Activation of the transcription factor NF-κB elicits an individually tailored transcriptional
response in order to meet the particular requirements of specific cell types, tissues, or …

DNA replication stress resulting from the activity of oncogenes such as MYC, is a common
feature of cancer cells. To cope with this challenge, tumours become addicted to ATR/CHK1 …

Sesquiterpene lactones have long been used in traditional Chinese medicines to treat
inflammatory diseases. Recently, sesquiterpene lactone family compounds have been …