Restless legs syndrome (RLS), also known as Willis–Ekbom Disease (WED), is a
sensorimotor disorder for which the exact pathophysiology remains unclear. Brain iron …

Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western
countries, has gained more and more attention in Asian countries. The prevalence of RLS is …

Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main
pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered …

In this article, we review the original findings from MRI and autopsy studies that
demonstrated brain iron status is insufficient in individuals with restless legs syndrome …

Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest
that there are two sources of hepcidin in the brain; one is local and the other comes from the …

Objective. Brain iron deficiency has been supposed to be involved in the pathophysiology of
ADHD. Available studies assessing iron in ADHD are based on serum ferritin, a peripheral …

BACKGROUND: Iron status is higher in the substantia nigra than in other brain regions but
can fluctuate as function of diet and genetics and disease. Of particular note is the …

Objective Restless legs syndrome (RLS) has serious effects on patients' sleep quality,
physical and mental health. However, the pathophysiological mechanisms of RLS remain …

Restless legs syndrome (RLS) is a common and often disabling sensorimotor disorder.
Epidemiologic studies suggest that RLS is an underrecognized and undertreated disorder …

The restless legs syndrome (RLS) is one of the commonest neurological sensorimotor
disorders at least in the Western countries and is often associated with periodic limb …