Confluence and convergence of Dscam and Pcdh cell-recognition codes

H Dong, J Li, Q Wu, Y Jin - Trends in Biochemical Sciences, 2023 - cell.com
The ability of neurites of the same neuron to avoid each other (self-avoidance) is a
conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the …

Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction

A Ptashnik, N LaMassa, A Mambetalieva… - Frontiers in Cell and …, 2023 - frontiersin.org
The family of∼ 60 clustered protocadherins (Pcdhs) are cell adhesion molecules encoded
by a genomic locus that regulates expression of distinct combinations of isoforms in …

Outward-oriented sites within clustered CTCF boundaries are key for intra-TAD chromatin interactions and gene regulation

X Ge, H Huang, K Han, W Xu, Z Wang, Q Wu - Nature Communications, 2023 - nature.com
CTCF plays an important role in 3D genome organization by adjusting the strength of
chromatin insulation at TAD boundaries, where clustered CBS (CTCF-binding site) elements …

[HTML][HTML] Visualization of trans-interactions of a protocadherin-α between processes originating from single neurons

T Kanadome, N Hoshino, T Nagai, T Yagi, T Matsuda - Iscience, 2023 - cell.com
Clustered protocadherin (Pcdh), a cell adhesion protein, is involved in the self-recognition
and non-self-discrimination of neurons by conferring diversity on the cell surface. Although …

The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex

WRM Leon, DM Steffen… - Proceedings of the …, 2024 - National Acad Sciences
Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into the
cortex where they make connections with locally produced excitatory glutamatergic neurons …

AC‐terminal motif containing a PKC phosphorylation site regulates γ‐Protocadherin‐mediated dendrite arborization in the cerebral cortex in vivo

CM Hanes, KM Mah, DM Steffen… - Developmental …, 2024 - Wiley Online Library
The Pcdhg gene cluster encodes 22 γ‐Protocadherin (γ‐Pcdh) cell adhesion molecules that
critically regulate multiple aspects of neural development, including neuronal survival …

[HTML][HTML] Astrocyte morphogenesis requires self-recognition

S Zipursky, J Lee, A Sergeeva, G Ahlsen… - Research …, 2024 - ncbi.nlm.nih.gov
Self-recognition is a fundamental cellular process across evolution and forms the basis of
neuronal self-avoidance1–4. Clustered protocadherins (Pcdh), comprising a large family of …

Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms

EJ May, R Gaudet - bioRxiv, 2024 - biorxiv.org
Proteins that transmit molecules and signals across the plasma membrane are crucial in cell
biology because they enable cells to sense and respond to their surroundings. A major …

Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex

Y Zhu, C Deng, L Fan, YQ Wang, H Zhou, H Xu - Elife, 2024 - elifesciences.org
In the process of synaptic formation, neurons must not only adhere to specific principles
when selecting synaptic partners but also possess mechanisms to avoid undesirable …

PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α and lipid metabolism reprogramming

L Celada, T Cubiella, L Salerno, J San-Juan-Guardado… - bioRxiv, 2024 - biorxiv.org
Clustered protocadherins (cPCDH) are widely expressed in the nervous system with known
functions, but their roles in cancer metastasis are largely unexplored. Our previous research …