Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

cellular apoptosis signaling kinase-1, a redox-sensitive kinase upstream of Jun-nuclear
kinase and p38. Apoptosis signaling kinase-1 overexpression activates nuclear factor κB to …

The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two
metabolic disorders often co-occur, and are part of what is often referred to as the metabolic …

Stress-activated signaling cascades are affected by altered redox potential. Key contributors
to altered redox potential are reactive oxygen species (ROS) which are formed, in most …

Myocardial ischemia and ischemia/reperfusion activate several protein kinase pathways.
Protein kinase activation potentially regulates the onset of myocardial cell injury and the …

Cardiac hypertrophy (CH) is an adaptive response of the heart to pressure overload. It is a
common pathological feature in the natural course of some major cardiovascular diseases …

The Na+-H+ exchange (NHE) is a major mechanism by which the heart adapts to
intracellular acidosis during ischemia and recovers from the acidosis after reperfusion …

Increasing evidence suggests that oxidative and nitrosative stress play an important role in
regulation of cardiac myocyte growth and survival. The cardiovascular system is …

Reactive oxygen species (ROS), including H2O2, cause intracellular calcium overload and
ischemia-reperfusion damage. The objective of this study was to examine the hypothesis …

Myocardial stretch elicits a rapid increase in developed force, which is mainly caused by an
increase in myofilament calcium sensitivity (Frank-Starling mechanism). Over the ensuing 10 …