Naphthalene, a versatile platform in medicinal chemistry: sky-high perspective

S Makar, T Saha, SK Singh - European journal of medicinal chemistry, 2019 - Elsevier
Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …

Convenient Synthesis and Anticancer Activity of Methyl 2-[3-(3-Phenyl-quinoxalin-2-ylsulfanyl)propanamido]alkanoates and N-Alkyl 3-((3-Phenyl-quinoxalin-2-yl) …

SM El Rayes, A Aboelmagd, MS Gomaa, IAI Ali… - ACS …, 2019 - ACS Publications
A series of methyl 2-[3-(3-phenyl-quinoxalin-2-ylsulfanyl) propanamido] alkanoates and their
corresponding hydrazides and N-alkyl 3-((3-phenylquinoxalin-2-yl) sulfanyl) propanamides …

Amino acid derivatives, part 4: synthesis and anti‐HIV activity of new naphthalene derivatives

NS Hamad, NH Al‐Haidery, IA Al‐Masoudi… - Archiv der …, 2010 - Wiley Online Library
A new series of 2‐(naphthalen‐2‐yloxy)‐N‐[(aryl‐5‐thioxo‐4, 5‐dihydro‐1H‐1, 2, 4‐triazol‐
3‐yl) methyl] acetamides 5a–f was synthesized from naphthalene‐derived glycine derivative …

Synthesis and antiviral evaluation of new N‐acylhydrazones containing glycine residue

B Tian, M He, Z Tan, S Tang, I Hewlett… - Chemical biology & …, 2011 - Wiley Online Library
N‐acylhydrazones containing glycine residue 3a–j and 8a–h were synthesized as HIV‐1
capsid protein assembly inhibitors. The structures of the novel N‐acylhydrazone derivatives …

Convenient Synthesis of N-Alkyl-2-(3-phenyl-quinoxalin-2-ylsulfanyl)acetamides and Methyl-2-[2-(3-phenyl-quinoxalin-2-ylsulfanyl)acetylamino]alkanoates

SM El Rayes, G El-Enany, MS Gomaa, IAI Ali… - ACS …, 2022 - ACS Publications
A series of 27 new quinoxaline derivatives (N-alkyl-[2-(3-phenyl-quinoxalin-2-ylsulfanyl)]
acetamides, methyl-2-[2-(3-phenylquinoxalin-2-ylsulfanyl)-acetylamino] alkanoates, and …

The synthesis and antiproliferative activity of new N-allyl quinoxalinecarboxamides and their O-regioisomers

A Aboelmagd, SM El Rayes, MS Gomaa… - New Journal of …, 2021 - pubs.rsc.org
We have designed a series of quinoxalinepeptidomimetic derivatives based on our
previously reported scaffold in an attempt to find a promising lead compound …

Synthesis and anti-HIV activity of new benzimidazole, benzothiazole and carbohyrazide derivatives of the anti-inflammatory drug indomethacin

NA Al-Masoudi, NNA Jafar, LJ Abbas… - … für Naturforschung B, 2011 - degruyter.com
There is an urgent need for the design and development of new and safer drugs for the
treatment of HIV infection, active against the currently resistant viral strains. New derivatives …

New aryl-1, 3-thiazole-4-carbohydrazides, their 1, 3, 4-oxadiazole-2-thione, 1, 2, 4-triazole, isatin-3-ylidene and carboxamide derivatives. Synthesis and anti-HIV …

M Zia, T Akhtar, S Hameed… - … für Naturforschung B, 2012 - degruyter.com
A series of isatin-3-ylidene (6a-i) and arylthiazolyl-1, 3, 4-oxadiazole-2-thione derivatives 7a-
i derived from arylthiazolyl carbohydrazide analogs 4a-i were synthesized. Analogously …

Efficient synthesis of 1‐substituted‐4‐phenyl‐1, 4‐dihydro‐5H‐tetrazole‐5‐thione and (1‐phenyl‐1H‐tetrazol‐5‐yl)thioacetyl derivatives

W Fathalla, IAI Ali - … Chemistry: An International Journal of Main …, 2007 - Wiley Online Library
A new and convenient synthesis of a variety of N‐and S‐substituted tetrazoles has been
developed via azide and Mannich reaction methods. Compounds were characterized by …

[PDF][PDF] Synthesis of chiral N-(2-(1-oxophthalazin-2 (1H)-yl) ethanoyl)-α-amino acid derivatives as antitumor agents

AOH El Nezhawy, MAA Radwan, ST Gaballah - Arkivoc, 2009 - arkat-usa.org
A series of chiral α-amino acid derivatives conjugated with 1-oxophthalazine moiety 5a-e
were synthesized by coupling of various L-acylated amino acid derivatives with 2-(1 …