Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …

Metallo-β-lactamases (MBLs) are zinc-dependent enzymes capable of hydrolyzing all
bicyclic β-lactam antibiotics, posing a great threat to public health. However, there are …

L1 is a dizinc subclass B3 metallo-β-lactamase (MBL) that hydrolyzes most β-lactam
antibiotics and is a key resistance determinant in the Gram-negative pathogen …

Our aim was to assess whether newer carbapenems with a better administration profile than
meropenem (ertapenem, faropenem and tebipenem) were more effective against …

Serial x-ray crystallography can uncover binding events, and subsequent chemical
conversions occurring during enzymatic reaction. Here, we reveal the structure, binding and …

Deactivation of the β-lactam antibiotics in the active sites of the β-lactamases is among the
main mechanisms of bacterial antibiotic resistance. As drugs of last resort, carbapenems are …

Antibiotic resistance (AR) remains one of the major threats to the global healthcare system,
which is associated with alarming morbidity and mortality rates. The defence mechanisms of …

New Delhi metallo-β-lactamase 1 (NDM-1) is an important causative factor of antimicrobial
resistance due to its efficient hydrolysis of a broad range of β-lactam compounds. The two …

Background: Carbapenem-resistant Enterobacterales (CRE) have been identified as a
public health problem. Treatment options for CRE are limited as they are mostly resistant to …

Time-Resolved β-lactam Cleavage by L1 Metallo-β- Lactamase Page 1 Time-Resolved β-lactam
Cleavage by L1 Metallo-βLactamase Andrzej Joachimiak (  andrzejj@anl.gov ) University …