Interactions governing transcriptional activity of nuclear receptors
The key players in transcriptional regulation are transcription factors (TFs), proteins that bind
specific DNA sequences. Several mechanisms exist to turn TFs 'on'and 'off', including ligand …
specific DNA sequences. Several mechanisms exist to turn TFs 'on'and 'off', including ligand …
Obesity-Linked PPARγ Ser273 Phosphorylation Promotes Beneficial Effects on the Liver, despite Reduced Insulin Sensitivity in Mice
MF Terra, M García-Arévalo, TM Avelino, KY Degaki… - Biomolecules, 2023 - mdpi.com
Since the removal of thiazolidinediones (TZDs) from the market, researchers have been
exploring alternative anti-diabetic drugs that target PPARγ without causing adverse effects …
exploring alternative anti-diabetic drugs that target PPARγ without causing adverse effects …
Design, synthesis and biological evaluation of cajanonic acid A analogues as potent PPAR γ antagonists
XT Xu, LY Shi, YJ Ban, BL Luo, GF Zhu, B Guo… - Bioorganic & Medicinal …, 2023 - Elsevier
Peroxisome proliferator-activated receptor γ (PPAR γ) antagonists are a key instrument of
insulin sensitizers since they have the ability to sensitize insulin and can avoid adverse …
insulin sensitizers since they have the ability to sensitize insulin and can avoid adverse …
Cardiac-selective gene delivery of medium-chain acyl-CoA dehydrogenase (MCAD) does not protect against diabetes-induced cardiac dysfunction
KL Weeks, H Kiriazis, NM Sergienko, AJA Raaijmakers… - 2023 - researchsquare.com
People with diabetes are at significantly higher risk of developing heart failure. Diabetic
cardiomyopathy describes heart disease in patients with diabetes who have no other …
cardiomyopathy describes heart disease in patients with diabetes who have no other …
[PDF][PDF] Análise molecular e funcional da modulação da fosforilação do PPARγ em camundongos alimentados com dieta hiperlipídica
MF Terra - 2022 - repositorio.unicamp.br
Obesidade é uma patologia caracterizada pelo acúmulo de tecido adiposo em proporções
que afetam a saúde dos indivíduos e tem atingido proporções epidêmicas no mundo. Esses …
que afetam a saúde dos indivíduos e tem atingido proporções epidêmicas no mundo. Esses …