[HTML][HTML] CSC radioresistance: a therapeutic challenge to improve radiotherapy effectiveness in cancer
MA Olivares-Urbano, C Griñán-Lisón, JA Marchal… - Cells, 2020 - mdpi.com
Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …
approximately 50% of all cancer patients either alone or in combination with other treatment …
[HTML][HTML] Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence
B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …
CD44+ lung cancer stem cell-derived pericyte-like cells cause brain metastases through GPR124-enhanced trans-endothelial migration
Brain metastasis of lung cancer causes high mortality, but the exact mechanisms underlying
the metastasis remain unclear. Here we report that vascular pericytes derived from CD44+ …
the metastasis remain unclear. Here we report that vascular pericytes derived from CD44+ …
A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on it
A Varone, JK Nguyen, L Leng, R Barrile, J Sliz… - Biomaterials, 2021 - Elsevier
Successful translation of in vivo experimental data to human patients is an unmet need and
a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to …
a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to …
A microfluidic platform integrating dynamic cell culture and dielectrophoretic manipulation for in situ assessment of endothelial cell mechanics
The function of vascular endothelial cells (ECs) within the complex vascular
microenvironment is typically modulated by biochemical cues, cell–cell interactions, and …
microenvironment is typically modulated by biochemical cues, cell–cell interactions, and …
Making use of noise in biological systems
Y Ilan - Progress in biophysics and molecular biology, 2023 - Elsevier
Disorder and noise are inherent in biological systems. They are required to provide systems
with the advantages required for proper functioning. Noise is a part of the flexibility and …
with the advantages required for proper functioning. Noise is a part of the flexibility and …
[HTML][HTML] The promise for histone methyltransferase inhibitors for epigenetic therapy in clinical oncology: a narrative review
Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …
specific gene expression in mammals. Changes in gene expression and malignant cellular …
[HTML][HTML] The role of tumor microenvironment on cancer stem cell fate in solid tumors
S Razi, A Haghparast, S Chodari Khameneh… - Cell Communication and …, 2023 - Springer
In the last few decades, the role of cancer stem cells in initiating tumors, metastasis,
invasion, and resistance to therapies has been recognized as a potential target for tumor …
invasion, and resistance to therapies has been recognized as a potential target for tumor …
Acquired resistance to targeted therapies in NSCLC: Updates and evolving insights
CB Meador, AN Hata - Pharmacology & therapeutics, 2020 - Elsevier
While significant advancements have been made in the available therapies for metastatic
non-small cell lung cancer (NSCLC), acquired resistance remains a major barrier to …
non-small cell lung cancer (NSCLC), acquired resistance remains a major barrier to …
Cell signaling and cancer: a mechanistic insight into drug resistance
Drug resistance is a major setback for advanced therapeutics in multiple cancers. The
increasing prevalence of this resistance is a growing concern and bitter headache for the …
increasing prevalence of this resistance is a growing concern and bitter headache for the …