Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …

Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

Brain metastasis of lung cancer causes high mortality, but the exact mechanisms underlying
the metastasis remain unclear. Here we report that vascular pericytes derived from CD44+ …

Successful translation of in vivo experimental data to human patients is an unmet need and
a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to …

The function of vascular endothelial cells (ECs) within the complex vascular
microenvironment is typically modulated by biochemical cues, cell–cell interactions, and …

Disorder and noise are inherent in biological systems. They are required to provide systems
with the advantages required for proper functioning. Noise is a part of the flexibility and …

Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …

In the last few decades, the role of cancer stem cells in initiating tumors, metastasis,
invasion, and resistance to therapies has been recognized as a potential target for tumor …

While significant advancements have been made in the available therapies for metastatic
non-small cell lung cancer (NSCLC), acquired resistance remains a major barrier to …

Drug resistance is a major setback for advanced therapeutics in multiple cancers. The
increasing prevalence of this resistance is a growing concern and bitter headache for the …