Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and
molecular mechanisms driving the invasive growth patterns and therapeutic resistance are …

Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for
tumor progression and therapy resistance. However, the determination of TM …

Glioblastoma (GBM) is a progressive and lethal brain cancer. Malignant control of actin and
microtubule cytoskeletal mechanics facilitates two major GBM therapeutic resistance …

Glioblastoma (GBM) is the most frequently diagnosed primary central nervous system tumor
in adults. Despite the standard of care therapy, which includes surgical resection …

Glioblastoma (GBM) is the most common brain tumor in adults, which is very aggressive,
with a very poor prognosis that affects men twice as much as women, suggesting that female …

Results Development of a connectivity signature for GB We first explored the transcriptomic
landscape of TM-connected human patient-derived glioblastoma cells (PDGCs). Three …

(1) Background: In the development of new and more effective anticancer approaches,
combined treatments appear of great interest. Combination therapy could be of importance …

In this study, a series of novel 4-Aryl-4H-chromene derivatives (D1-D31) were designed and
synthesized by integrating quinoline heterocycle to crolibulin template molecule based on …