Background There are many biomarkers associated with breast cancer. Higher expression
of PIK3CA (Phosphoinositide 3-kinase Cα), in its upregulated form, is associated with Hr+ …

Neuroinflammation is a typical feature of many neurodegenerative diseases, including
Alzheimer's disease and Parkinson's disease. Microglia, the resident immune cells of the …

This paper deals with in silico evaluation of newly proposed heterocyclic derivatives in
search of potential anticancer activity. Best possible drug candidates have been proposed …

Pharmacokinetics and toxicity profile along with efficacy are the major determinants for
successful drug development. This study was carried out to determine the pharmacokinetic …

Background Cucumis prophetarum is traditionally used to treat liver and lung disorders,
heart failure, diarrhea, gonorrhea, skin infections, intestinal problems and cancer. In the …

Phenolic compounds, among them isopropyl caffeate, possess antioxidant potential, but not
without toxicity and/or adverse effects. The present study aimed to evaluate the antioxidant …

Objective: Phenolic compounds, such as flavonoids, have aroused great scientific interest
due to their diverse pharmacological activities. Several studies suggested that flavonoids act …

In viral binding and entry, the Spike (S) protein of SARS-CoV-2 uses transmembrane serine
protease 2 (TMPRSS2) for priming to cleavage themselves. In this study, we have screened …

Objective: This investigation includes characterization of phytochemicals from acetone
extract of Helianthus annuus L. seeds responsible for αamylase and α-glucosidase …

Natural products continue today, in a never-ending quest, to provide new lead compounds.
Yet, the path to a marketed drug involves a long and exhaustive journey through basic …